By Ramana S. Moorthy, MD
A dialogue of the scientific method of uveitis ends up in greatly rewritten chapters on noninfectious (autoimmune) and infectious kinds of uveitis. additionally coated are endophthalmitis, masquerade syndromes, and issues of uveitis. A dialogue on ocular involvement in AIDS has been up-to-date. The part on immunology describes the human immune reaction in phrases that make it hugely available to readers.
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Additional info for 2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009)
The vitreous gel can electrostatically bind charged protein substances and may thus serve as an antigen depot as well as a substrate for leukocyte cell adhesion. Because the vitreous contains type II collagen, it may serve as a depot of potential auto antigen in some forms of uveitis related to arthritis in which type II collagen in the joint is an autoantigen. See also BCSC Section 12, Retina and Vitreous. Immunoregulatory Systems The anterior uvea has an immunoregulatory system that has been described as immune privilege.
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Basic immunology. In: Foster CS, Vitale AT, eds. Diagnosis and Treat- ment of Uveitis. Philadelphia: Saunders; 2002:34-78. Sugita S, Ng TF, Lucas PJ, Gress RE, Streilein Jw. B7+ iris pigment epithelium T regulatory cells; both suppress CTLA-4+ T cells. J Immunol. 2006;176:118Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein Jw. lhrombospondin immune privilege of the eye. Invest Ophthalmol CLINICAL induce CD8+ 127. plays a vital role in the Vis Sci. 2005;46:908-919. EXAMPLE3-2 Therapeutic potential of immune privilege It is has practical consequences for clinical diseases, unknown whether although it is thought a role in immunologic tolerance to lens crystallins after in immunologic acceptance of corneal transplantation.
2008-2009 Basic and Clinical Science Course: Section 9: Intraocular Inflammation and Uveitis (Basic and Clinical Science Course 2008-2009) by Ramana S. Moorthy, MD