By Y. Sawamura, N. de Tribolet (auth.), L. Symon, L. Calliauw, F. Cohadon, B. Guidetti, F. Loew, H. Nornes, E. Pásztor, B. Pertuiset, J. D. Pickard, M. G. Yaşargil (eds.)

ISBN-10: 3709169259

ISBN-13: 9783709169254

ISBN-10: 3709174368

ISBN-13: 9783709174364

As an addition to the eu postgraduate education approach for younger neurosurgeons we started to submit in 1974 this sequence dedicated to Advances and Technical criteria in Neurosurgery which was once later backed through the ecu organization of Neurosurgical Societies. the truth that the English language is easily which will changing into the foreign medium at eu clinical meetings is a brilliant asset when it comes to mutual knowing. hence we've got made up our minds to post all contributions in English, whatever the local language of the authors. All contributions are submitted to the whole editorial board earlier than book of any quantity. Our sequence isn't meant to compete with the courses of unique clinical papers in different neurosurgical journals. Our goal is, fairly, to give fields of neurosurgery and similar parts during which very important contemporary advances were made. The contributions are written by way of experts within the given fields and represent the 1st a part of each one quantity. within the moment a part of every one quantity, we put up targeted descriptions of ordinary operative methods, supplied through skilled clinicians; in those articles the authors describe the thoughts they hire and clarify the benefits, problems and hazards focused on some of the strategies. This half is meant essentially to help younger neurosurgeons of their publish­ graduate education. notwithstanding, we're confident that it'll even be valuable to skilled, totally educated neurosurgeons.

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1988, Itho et al. 1986, Kradin et al. 1987, Muul et al. 1987, Rabinowich et al. 1987, Rosemberg et al. 1986, Sawamura et al. 1988 a, 1989). However it has been found that glioma-infiltrating lymphocytes cultured in the presence of IL 2 have a strikingly reduced proliferative potential (Miescher et al. 1988). Recently we investigated the possibility of glioma-derived TIL for clinical use. If TIL are to be more effective in vivo as adoptively transferred effector cells than LAK, the following requirements have to be fulfilled in vitro (Rosenberg et al.

While this concept has been considered for many years, its realization has been hampered by major obstacles which include the following: 1) All antigens recognized by the MAb produced so far are known to have some secondary representation on other cells. In order for MAb directed therapy to be safe, the antigens must be fully characterized as discussed above and their expression on normal cells must be minimal. 2) The possibility of an anaphylactic reaction always exists, especially if MAb are employed repeatedly.

Br J Cancer 48: 819-825 30. Brady LW, Woo DV, Karlsson U, Steplewski Z, Rackover M, Koprowski H (1988) Radioimmunotherapy of human gliomas using I -125 labeled monoclonal antibody to epidermal growth factor receptor. Proceedings of ASCO 7: p 83 46 Y. SAWAMURA and N. DE TRIBOLET 31. Braun DP, Penn RD, Flannery AM, Harris JE (1982) Immunoregulatory cell-function in peripheral blood leukocytes of patients with intracranial gliomas. Neurosurgery lO: 203-209 32. Braun DP, Penn RD, Harris JE (1984) Regulation of natural killer cell function by glass-adherent cells in patients with intracranial malignancies.

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Advances and Technical Standards in Neurosurgery by Y. Sawamura, N. de Tribolet (auth.), L. Symon, L. Calliauw, F. Cohadon, B. Guidetti, F. Loew, H. Nornes, E. Pásztor, B. Pertuiset, J. D. Pickard, M. G. Yaşargil (eds.)

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