By Melody A. Cobleigh M.D. (auth.), William J. Gradishar M.D., William C. Wood M.D. (eds.)

ISBN-10: 1475731477

ISBN-13: 9781475731477

ISBN-10: 1475731493

ISBN-13: 9781475731491

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52. 53. 54. 55. 56. 57. 58. 59. 60. 19 Rimm EB, Willett WC, Hu FB, et al. Folate and vitamin B6 from diet and supplements in relation to the risk of coronary heart disease among women. JAMA 1998; 279:359. Bines J, Oleske DM, Cobleigh MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Onco11996; 14:1718. Mansour EG, Gray R, Shatila AH, et al. Efficacy of adjuvant chemotherapy in high-risk node-negative breast cancer. N Engl J Med 1989; 320:485 The Ludwig Breast Cancer Study Group.

41. 42. 43. 44. 45. 46. 47. 48. 49 after mastectomy is not an indication for chest wall irradiation except in women aged fifty or younger. Int J Radiat Oncol Bioi Phys 41 :599-605, 1998. Fowble B, Gray R, Gilchrist K, et al: Identification of a subgroup of patients with breast cancer and histologically positive axillary nodes receiving adjuvant chemotherapy who may benefit from postoperative radiotherapy. J Clin Oncol6: 1107-1117, 1988. Sykes HF, Sim DA, Wong CJ, et al: Local-regional recurrence in breast cancer after mastectomy and adriamycin-based adjuvant chemotherapy: evaluation of the role of postoperative radiotherapy.

42 The number of involved nodes and tumor size both exerted statistically significant effects on this risk in a multivariate analysis, while patient age and estrogen-receptor protein level did not. However, the actual rates of failure in such patient subgroups were not described. 1 years. The first site of failure was: isolated LRF, 254 (13%); LRF with simultaneous distant failure, 166 (8%); and distant only, 679 (34%). The total risk of LRF at 10 years was 13% in patients with 1 to 3 positive nodes and 29% for patients with 4 or more positive nodes.

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Advances in Breast Cancer Management by Melody A. Cobleigh M.D. (auth.), William J. Gradishar M.D., William C. Wood M.D. (eds.)


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