By Antonio Giordano, Kenneth J. Soprano

ISBN-10: 0896039307

ISBN-13: 9780896039308

Major clinicians and investigators overview in a understandable and uncomplicated variety the entire most up-to-date information regarding the molecular biology of mobilephone cycle regulate and exhibit its scientific relevance to knowing neoplastic illnesses. themes variety from Cdk inhibitors and mobile cycle regulators to the prognostic price of p27 and tumor suppressor genes as diagnostic instruments. genuine case experiences exhibit how the recent molecular figuring out has produced such medicinal drugs as Flavopiridol and Sulindac. The booklet brings the entire fresh serious learn findings to undergo on medical perform, and obviously exhibits their strong impression at the diagnostics, prognostics, and therapeutics of melanoma, AIDS, and heart problems.

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Additional resources for Cell Cycle Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development)

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Reversible changes in the nucleosomal organization of a human H4 histone gene during the cell cycle. Biochemistry 1986;25:5364–5370. 53. Pemov A, Bavykin S, Hamlin JL. Proximal and long-range alterations in chromatin structure surrounding the Chinese hamster dihydrofolate reductase promoter. Biochemistry 1995; 34:2381–2392. Transcriptional Control of Cell Cycle 47 54. Ljungman M. Effect of differential gene expression on the chromatin structure of the DHFR gene domain in vivo. Biochim Biophys Acta 1996;1307:171–177.

6. Fridovich-Keil JL, Markell PJ, Gudas JM, Pardee AB. DNA sequences required for serumresponsive regulation of expression from the mouse thymidine kinase promoter. Cell Growth Differ 1993;4:679–687. 7. Dou QP, Zhao S, Levin AH, Wang J, Helin K, Pardee AB. G1/S-regulated E2F-containing protein complexes bind to the mouse thymidine kinase gene promoter. J Biol Chem 1994;269:1306–1313. 8. Dou QP, Molnar G, Pardee AB. Cyclin D1/cdk2 kinase is present in a G1 phase-specific protein complex Yi1 that binds to the mouse thymidine kinase gene promoter.

Wiggan O, Taniguchi-Sidle A, Hamel PA. Interaction of the pRB-family proteins with factors containing paired-like homeodomains. Oncogene 1998;16:227–236. 37. Gartel AL, Goufman E, Tevosian SG, Shih H, Yee AS, Tyner AL. Activation and repression of p21(WAF1/CIP1) transcription by RB binding proteins. Oncogene 1998;17:3463–3469. 38. Thomas DM, Carty SA, Piscopo DM, Lee JS, Wang WF, Forrester WC, Hinds PW. The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation.

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Cell Cycle Inhibitors in Cancer Therapy (Cancer Drug Discovery and Development) by Antonio Giordano, Kenneth J. Soprano


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