By Rong-Fu Wang (auth.), Rongfu Wang (eds.)
Innate and adaptive immunity play very important roles in immunosurveillance and tumor destruction. notwithstanding, expanding facts means that tumor-infiltrating immune cells can have a twin functionality: inhibiting or selling tumor development and development. even supposing regulatory T (Treg) cells result in immune tolerance through suppressing host immune responses opposed to self- or non self-antigens, therefore taking part in serious roles in fighting autoimmune ailments, they could inhibit antitumor immunity and advertise tumor development. fresh reviews reveal that increased proportions of Treg cells are found in numerous sorts of cancers and suppress antitumor immunity. in addition, tumor-specific Treg cells can inhibit immune responses in simple terms after they are uncovered to antigens provided via tumor cells. for this reason, Treg cells at tumor websites have unsafe results on immunotherapy directed to melanoma.
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Extra resources for Innate Immune Regulation and Cancer Immunotherapy
2004a, b). Vd1+ cells also recognize glycolipids presented by CD1c on the surface of immature dendritic cells and can induce DC to mature and produce IL-12 (Spada et al. 2000; Ismaili et al. 2002; Leslie et al. 2002). Vd1+ T cells can also exhibit immunosuppressive and regulatory properties, a function which is discussed at greater length below. Vd1+ T cells infiltrate and kill a wide variety of lymphoid and myeloid malignancies (Duval et al. 1995; Groh et al. 1999; Dolstra et al. 2001; Lamb et al.
2009). These findings suggest that N-BP compounds have a dual role in the initiation of innate antitumor immune response both by activating and by expanding Vg9Vd2+ T cells and by rendering selected tumors more vulnerable to Vg9Vd2+ T cell-mediated lysis. As discussed above, NKG2D activation is also an important factor in tumor recognition and lysis by Vg9Vd2+ T cells, potentially playing a costimulatory role 3 γ δ T Cells in Cancer 27 in cooperation with TCR-dependent activation (Das et al. 2001; Wrobel et al.
1999; Medzhitov et al. 1997; Poltorak et al. 1998; Schwandner et al. 1999; Takeuchi et al.
Innate Immune Regulation and Cancer Immunotherapy by Rong-Fu Wang (auth.), Rongfu Wang (eds.)