By S. Srivastava

ISBN-10: 9535104101

ISBN-13: 9789535104100

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Additional info for Pancreatic Cancer - Molecular Mechanism and Targets

Sample text

Dietary components are beginning to be observed as major determinants of cancer risk in humans (18-22). Nutrition can potentially modify, through epigenetic mechanisms molecular changes associated with carcinogenesis. Furthermore, employing this new science in understanding how bioactive components can affect the constant insults from external and internal factors to DNA, which results in chromatin changes, alteration in DNA repair, apoptosis and inflammation epigenetically will enhance our knowledge on pancreatic cancer.

16] Davis CD, Miner J. 2004. Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutation Research 551(1-2):51-64. 26 Pancreatic Cancer – Molecular Mechanism and Targets [17] Elliott R, Ong TJ. 2002. Nutritional genomics. BMJ 324(7351):1438-1442. [18] Oak MH, El Bedoui J, Schini-kerth VB. 2005. Antiangiogenic properties of natural polyphenols from red wine and green tea. J. Nutr Biochem 16(1):1-8. [19] Chan MM. 1995. Inhibition of tumor necrosis factor by curcumin, a phytochemical.

102] Howe GR and Burch JD. 1996. Nutrition and Pancreatic Cancer. Cancer Causes and Control 7:69-82. [103] De Gonzalez AB, Sweetland S, Spencer E. A meta-analysis of obesity and risk of pancreatic cancer. British J Cancer 89:519-523. [104] Hursting S, Smith SM, Lashiger LM, Harvey AE, Perkins SN. 2010. Calories and Carcinogenesis: lessons learned from 30 years of caloric restriction research. Carcinogenesis 31(1):83-89. Epigenetics and Pancreatic Cancer: The Role of Nutrigenomics 31 [105] Silver DT, Hoover RN, Brown LM, Swanson GM, et al.

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Pancreatic Cancer - Molecular Mechanism and Targets by S. Srivastava

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